New weapon for inflammation

Credit: CC0 Public Domain

Flinders University researchers have discovered a new anti-inflammatory role for well-known blood clot protein fibrinogen, which could support targeted new treatments for kidney, heart and other common diseases.

The study in Redox Biology describes how fibrinogen can be protective against hypochlorite—a chemical generated by the body during inflammation—and so act as a kind of antioxidant in .

“Our team found that fibrinogen, which forms extraordinarily large assemblies when it reacts with hypochlorite, doesn’t harm cells in the same way as hypochlorite-modified which exacerbates kidney and , and many other serious health conditions,” says research leader Dr. Amy Wyatt, from the Flinders College of Medicine and Public Health.

“While fibrrinogen is less abundant than the main blood protein albumin, it’s more susceptible to reacting with hydrochlorite in the body.”

The accumulation of hypochlorite-modified albumin can cause harm in a patient, however hypochlorite-modified fibrinogen seems relatively harmless. This discovery could ultimately help us to design therapies that block the bad effects of hypochlorite-modified albumin,” Dr. Wyatt says.

“When we figure out precisely how these distinctly different behave, then it might be possible to block the disease-promoting activities of hypochlorite-modified albumin using drugs,” say the Flinders research group mapping how protein molecules normally function and how these functions change when protein molecules are damaged by biological stresses such as reaction with hypochlorite.

Additionally, the scientists say the research could reveal new biomarkers for inflammatory disease.

Researchers develop a new approach to detect pancreatic cancer

More information:
Noralyn Mañucat-Tan et al, Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in blood plasma, Redox Biology (2020). DOI: 10.1016/j.redox.2020.101847

New weapon for inflammation (2021, February 1)
retrieved 1 February 2021

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

Source link

3 thoughts on “New weapon for inflammation”

Leave a Comment

Your email address will not be published.

Durex condom

Durex Condoms for Men - 10 Count (Pack of 3) | Suitable for use with lubes & toys

%d bloggers like this: